Is a .223 round going to put a target down? Not immediately. It is going to leave an exit wound the size of a baseball more than likely though. It may not knock you out of the fight right away, but it will Injure you.
In a home defense situation, your cant take that risk, you need something that is going to put the target down, so IMO you need to go with a bigger caliber. Bigger bullet traveling at slower velocity = a whole world of hurt and more than likely death.
HOWEVER, from a tactical standpoint, killing your enemy isnt always whats best. Sometimes its better to injure as many people as you can. The more people you injure, the more people you take out of the fight.
It works like this: Say you have a 12 man squad. 4 of them get shot up. One medic isnt going to be able to care for four people, which means you start pulling from the squad. While their primary mission is to engage the enemy, 90 percent of the time your squad are your buddies and your going to want to save them. The 4 guys who got shot all have massive hemorrhaging and a couple have sucking chest wounds. Its going to take a lot of effort to keep them alive and kicking, so your looking at taking at least another 4 guys from the squad to care for them. That is now 8 guys who are out of the fight, and you only had to shoot four.
If you kill someone, they may or may not want the body, and even if they do, they dont need to care for it once the recover it.
From a tactical standpoint, tis much better to use the .223 because its lighter, causes significant damage, and is capable from firing from a variety of weapons.